α-Sulfoquinovosylmonoacylglycerol Is a Novel Potent Radiosensitizer Targeting Tumor Angiogenesis

摘要: Angiogenesis is a promising target for the treatment of cancer, and varying types antiangiogenic agents have been developed. However, limitations problems associated with therapy recently arisen. Although radiotherapy can be combined compounds to overcome these difficulties, almost all previously described angiogenesis inhibitors could still cause side effects at effective doses, only additive are seen in current combination therapy. In this study, we identified member sulfoquinovosylacylglycerols, α-sulfoquinovosylmonoacylglycerol (α-SQMG), originally derived from sea urchins, as potent radiosensitizer. The agent synergistically inhibits low doses when ionizing radiation. Combined α-SQMG radiation seems promote adoption senescence-like phenotype by vascular endothelial cells. Finally, remarkably enhances radioresponse human tumors transplanted into nude mice, accompanied significant reduction vascularity tumors. Collectively, may novel radiosensitizer targeting angiogenesis. (Cancer Res 2006; 66(4): 2287-95)