Combined effects of angiostatin and ionizing radiation in antitumour therapy

摘要: Angiogenesis, the formation of new capillaries from pre-existing vessels, is essential for tumour progression1,2,3,4,5. Angiostatin, a proteolytic fragment plasminogen6 that was first isolated serum and urine tumour-bearing mice7, inhibits angiogenesis thereby growth primary8 metastatic7,9,10 tumours. Radiotherapy important in treatment many human cancers, but often unsuccessful because cell radiation resistance11,12. Here we combine with angiostatin to target vasculature genetically stable therefore less likely develop resistance13,14,15. The results show an antitumour interaction between ionizing four distinct types, at doses are used radiotherapy. combination produced no increase toxicity towards normal tissue. In vitro studies have combined cytotoxic effects on endothelial cells, not cells. vivo these agents, combination, vasculature. Our provide support combining improve eradication without increasing deleterious effects.