How hydrophobically modified chitosans are stabilized by biocompatible lipid aggregates.

摘要: Abstract Nanostructured hydrogels composed by biocompatible molecules are formulated and characterized. They based on a polymer network formed hydrophobically modified chitosans (HMCHIT or CnCHIT) in which vesicles of monoolein (MO) oleic acid sodium oleate (NaO), depending pH , embedded. The best conditions for gel formation, terms length the hydrophobic moieties chitosan, weight proportion among three components were estimated visual inspection large number samples. Among all possible combinations, system C12CHIT–MO–NaO (1:1:1) is optimal formation well-structured gel-like system, also confirmed rheological experiments. Electron paramagnetic resonance (EPR) measurements unambiguously show presence lipid bilayers this mixture, indicating that MO–NaO stabilized C12CHIT even at . A wide small angle neutron scattering investigation performed several ternary systems general formula CnCHIT–MO–NaO shows tail Cn crucial parameter stabilizing Structural parameters determined using multilamellar model admits possibility displacement center each shell. shells tends to be reduced increasing content. thickness distance between consecutive lamellae not influenced either concentration. hydrogel presented work, being fully nanostructured, well-suited application drug delivery.