Carotid endarterectomy impairs blood pressure homeostasis by reducing the physiologic baroreflex reserve.

摘要: Objective To assess the impact of carotid endarterectomy on blood pressure homeostasis and baroreflex function, with particular reference to presence or absence significant contralateral artery disease, we conducted a prospective study in 80 patients symptomatic extracranial disease undergoing regional teaching hospital over 2 years. Methods Patients were divided into two groups: control group (n = 37) had no disease; diseased 23) either >70% stenosis occlusion artery. Seventeen abnormal heart rhythms, poor quality recordings, intermediate degrees excluded. Three who previously undergone separately evaluated. Atheromatous plaque was removed from lumen mechanism received direct intraoperative stimulation before after endarterectomy. The main outcome measures (1) hemodynamic response endarterectomy, sensitivity, operating set point (the resting pressure, which maintains) removal atheromatous plaque, (2) responsiveness ipsilateral baroreceptor stimulation. these variables also Results groups comparable for preoperative demographic, medication, variables. Carotid led rise mean arterial 81.3 ± 3.9 mm Hg 103.5 4.6 ( P Conclusions impairs through surgical destruction mechanism. have reduced reserve show greater dysfunction instability These are at risk postendarterectomy complications should be monitored closely.