Effect of hydrophilic soft segment side chains on the surface properties and blood compatibility of segmented poly(urethaneureas).
作者： Atsushi Takahara , Ann Z. Okkema , Hugh Wabers , Stuart L. Cooper
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摘要: Segmented poly(urethaneureas) with hydrophilic side chains were prepared from poly(tetramethylene oxide) (PTMO), 4,4'-diphenylmethane diisocyanate (MDI), ethylene diamine (ED) and a diol long chain comprised of an oxide-proplene oxide copolymer. The end groups the either sodium sulfonate or methoxy groups. state microphase separation showed small dependence on fraction long-chain diol. Surface analysis by means static underwater contact angle dynamic measurements revealed that graft at aqueous interface in hydrated state. An ex vivo A-V shunt experiment more thrombogenic blood-material response was correlated increase concentration polymeric incorporation. polyurethane containing exhibited higher level thrombogenicity than similar polymers possessing terminated chain.
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