The action of pancreatic lipase on stereoisomeric triglycerides.

摘要: Abstract d -, l and dl -α,β-dipalmitin were acylated with oleic acid to the corresponding oleoyl- - -α,β-dipalmitin. Each of these isomers yielded, after hydrolysis pancreatic lipase, an equimolecular mixture palmitic acids, optically inactive diglycerides containing acids in molar ratio 1:3. After triolein α,β-diolein formed was found be inactive. These results confirm conclusion other workers that lipase is specific for primary ester linkages triglycerides. The present evidence further establishes enzyme shows no preference one groups over other, but hydrolyzes both at same rate. mechanism enzymic therefore random not stereospecific.