Bortezomib congeners induce apoptosis of hepatocellular carcinoma via CIP2A inhibition.
作者： Duen-Ren Hou , Ann-Chi Huang , Chung-Wai Shiau , Chun-Yi Wang , Hui-Chuan Yu
DOI: 10.3390/MOLECULES181215398
关键词:
摘要: CIP2A is an oncoprotein that upregulates p-Akt and promotes cancer cell proliferation survival. The proteasome inhibitor bortezomib has been shown to reduce lead apoptosis. Here; we modified the functional group of generate a series novel compounds conducted structure-activity relationship (SAR) study. results showed compound 1 was able repress expression apoptosis in same manner as bortezomib, but with less potency inhibition activity. This finding provides new direction for design inhibitors.
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