Prioritising Causal Genes at Type 2 Diabetes Risk Loci.

作者: Antje K. Grotz , Anna L. Gloyn , Soren K. Thomsen

DOI: 10.1007/S11892-017-0907-Y

关键词:

摘要: Genome-wide association studies (GWAS) for type 2 diabetes (T2D) risk have identified a large number of genetic loci associated with disease susceptibility. However, progress moving from signals through causal genes to functional understanding has so far been slow, hindering clinical translation. This review discusses the benefits and limitations emerging, unbiased approaches prioritising at T2D loci. Candidate can be by different strategies that rely on data, genomic annotations, screening selected genes. To overcome each particular method, integration multiple data sets is proving essential establishing confidence in prioritised Previous also highlighted need support these efforts identification variants disease-relevant tissues. Prioritisation integrating complementary lines evidence promises accelerate our pathology promote translation into new therapeutics.

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