Preventive role of Pycnogenol® against the hyperglycemia-induced oxidative stress and DNA damage in diabetic rats.
作者： Sevtap Aydın , Merve Bacanlı , Hatice Gül Anlar , Tuğbagül Çal , Nuray Arı
DOI: 10.1016/J.FCT.2018.11.038
关键词:
摘要: ABSTACT Diabetes mellitus, a complex progressive metabolic disorder, leads to some oxidative stress related complications. Pycnogenol® (PYC), plant extract obtained from Pinus pinaster, has been suggested be effective in many diseases including diabetes, cancer, inflammatory and immune system disorders. The mechanisms underlying the effects of PYC diabetes need elucidated. aim this study was determine treatment (50 mg/kg/day, orally, for 28 days) on DNA damage biochemical changes blood, liver, kidney tissues experimental diabetic rats. Changes activities catalase, superoxide dismutase, glutathione peroxidase, reductase, glutathione-S-transferase enzymes, levels 8-hydroxy-2′-deoxyguanosine, total glutathione, malondialdehyde, insulin, bilirubin, alanine aminotransferase, aspartate gamma-glutamyl transferase, high density lipoprotein, low cholesterol, triglyceride were evaluated. also determined whole blood cells liver renal tissue using alkaline comet assay. significantly ameliorated stress, lipid profile, function parameters as well hyperglycemic results show that might improve hyperglycemia-induced physiological diabetes.
sci-hub.se 参考文章(83)
Shao Chin Lee, Juliana CN Chan, Evidence for DNA damage as a biological link between diabetes and cancer. Chinese Medical Journal. ,vol. 128, pp. 1543- 1548 ,(2015) , 10.4103/0366-6999.157693
Om P. Gulati, Pycnogenol® in Metabolic Syndrome and Related Disorders Phytotherapy Research. ,vol. 29, pp. 949- 968 ,(2015) , 10.1002/PTR.5341
Pei Chen, Fenhong Song, Long-Ze Lin, Chromatographic fingerprint analysis of Pycnogenol dietary supplements. Journal of AOAC International. ,vol. 92, pp. 624- 632 ,(2009) , 10.1093/JAOAC/92.2.624
Etiane Tatsch, José A.M.De Carvalho, Bruna S. Hausen, Yãnaí S. Bollick, Vanessa D. Torbitz, Thiago Duarte, Rogério Scolari, Marta M.M.F. Duarte, Sílvia W.K. Londero, Rodrigo A. Vaucher, Melissa O. Premaor, Fabio V. Comim, Rafael N. Moresco, Oxidative DNA damage is associated with inflammatory response, insulin resistance and microvascular complications in type 2 diabetes Mutation Research. ,vol. 782, pp. 17- 22 ,(2015) , 10.1016/J.MRFMMM.2015.10.003
Sridevi Devaraj, Sonia Vega-López, Nalini Kaul, Frank Schönlau, Peter Rohdewald, Ishwarlal Jialal, Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile Lipids. ,vol. 37, pp. 931- 934 ,(2002) , 10.1007/S11745-006-0982-3
Kehkashan Parveen Kehkashan Parveen, MR Khan, M Mujeeb, WA Siddiqui, Protective effects of Pycnogenol® on hyperglycemia-induced oxidative damage in the liver of type 2 diabetic rats Chemico-Biological Interactions. ,vol. 186, pp. 219- 227 ,(2010) , 10.1016/J.CBI.2010.04.023
CFM Sier, FJGM Kubben, S Ganesh, MM Heerding, G Griffioen, R Hanemaaijer, JHJM van Krieken, CBHW Lamers, HW Verspaget, Tissue levels of matrix metalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma. British Journal of Cancer. ,vol. 74, pp. 413- 417 ,(1996) , 10.1038/BJC.1996.374
P. Rohdewald, A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. principles and practice of constraint programming. ,vol. 40, pp. 158- 168 ,(2002) , 10.5414/CPP40158
S. Kushwaha, G.B. Jena, Telmisartan ameliorates germ cell toxicity in the STZ-induced diabetic rat: Studies on possible molecular mechanisms Mutation Research-genetic Toxicology and Environmental Mutagenesis. ,vol. 755, pp. 11- 23 ,(2013) , 10.1016/J.MRGENTOX.2013.04.013
David V. Godin, Saleh A. Wohaieb, Maureen E. Garnett, A. D. Goumeniouk, Antioxidant enzyme alterations in experimental and clinical diabetes. Molecular and Cellular Biochemistry. ,vol. 84, pp. 223- 231 ,(1988) , 10.1007/BF00421057