Improvement of nutritional status and lung function after long-term nocturnal gastrostomy feedings in cystic fibrosis

摘要: Abstract We investigated weight gain and clinical course of 14 patients with cystic fibrosis (CF), aged 7 to 23 years, who received long-term nocturnal supplemental feedings by means percutaneous endoscopic gastrostomies (PEGs). The (nine female, five male) were moderately malnourished; the weight-for-height value was 77.8% (SD 6.4%) predicted value. Lung function tests revealed severe airway obstruction; mean vital capacity 46.1% 14.4%), forced expiratory volume in 1 second (FEV ) 30.8% 12.3%) A nonelemental formula providing 35% total energy from fat used for feedings. 800 1500 kcal per night slow intragastric infusions. Enteric-coated pancreatic microsphere preparations taken orally just before bedtime. After year feedings, body had increased 6.0 kg 3.6 kg) 9.0% 6.1%) compared baseline values. also improved significantly: 8.2% 6.3%) FEV 3.9% 4.2%) values ( p