Immunoadjuvant Action of Liposomes: Mechanisms

摘要: A large variety of antigens may initiate a series events, finally leading to the production specific antibodies by defined cells belonging B cell lineage immune system. The immunogenicity these depend on different cellular requirements. Many (e.g. proteins and erythrocytes) need help T-lymphocytes start an response. These are referred as thymus-dependent (TD) which evoke TD number other have capability response without T-lymphocytes. thymus-independent (TI) TI Apart from B-lymphocytes, most require participation mononuclear phagocyte system (dendritic or macrophages). Although many immunologists nowadays seem consider purely in vitro phenomenon, belongs body (Marx, 1985), where antigens, their products opportunity meet each under optimum conditions. Evidence is growing that it microenvironment lymphoid organ, for there no equivalent, creates conditions cooperate either directly through products. possible interactions during spleen localization migration participating splenic compartments been recently reviewed (Van Rooijen et al, 1986). Herein we also postulated single differentiation pathway all antibody-forming spleen, independent antigen type We believe this running along be required any particular