Antigen presentation by B cells and macrophages of cytochrome c and its antigenic fragment when conjugated to the surface of liposomes
作者： Paul R. Dal Monte , Francis C. Szoka
DOI: 10.1016/0264-410X(89)90153-9
关键词:
摘要: An in vitro antigen presentation system was used to study how antigens coupled the surface of phospholipid vesicles (liposomes) are presented specific T cells. Liposome-bound pigeon cytochrome c (PCC) 30–40-fold more potent than free PCC when peritoneal macrophages were presenting cell. B cells surface-bound PCC, albeit less efficiently unmodified PCC. Surface-bound peptide epitope by both cell types, but not as peptide. With epitope, processing required since glutaraldehyde fixed could present
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