Recombinant porcine somatotropin: an immunotoxicology study.

摘要: The present study was designed to determine the effect of recombinant porcine somatotropin (rpST; 5, 15, or 25 mg.pig-1.d-1 for 57 d) on a variety immune function variables. We observed no significant rpST treatment gross pathology pigs, histopathology system organs, total and differential white blood cell counts, lymphocyte blastogenic response mitogens, neutrophil functions chemotaxis, ingestion, reduction cytochrome C, iodination, antibody-dependent cell-mediated cytotoxicity. Those variables that were significantly affected by include decreased hemoglobin packed red volume (at some time points all three dosages), decrease in plasma protein level at 25-mg dose, small increase random migration IgG antibody tetanus toxoid 15 d after immunization (but not 8, 22, 29). Additionally, associated with rate BW gain 15-mg dose), increased liver kidney weights dosage levels), an incidence renal tubular cytoplasmic vacuolation minor severity. There differences overall health pigs due treatment, based clinical observations as well determination titer to, isolation of, common swine pathogens. Therefore, there evidence influence would be clinically relevant.