Spatial extent of pigment epithelial detachments in age-related macular degeneration.

摘要: Abstract Objective To quantify the spatial extent of pigment epithelial detachment (PED) associated with age-related macular degeneration (AMD) using a rapid, noninvasive method. Design Prospective, cross-sectional study. Participants The authors tested 32 eyes 21 patients (13 women and 8 men) AMD 56 to 91 years age (mean = 72.8 years). retested seven six patients. Intervention Three-dimensional imaging quantification PED were performed in each subject confocal infrared (790 nm) Topographic Scanning System (TopSS). data consisted series images within 3-mm-depth range requiring 0.9 second. calculations made from series. Main outcome measure Height, diameter, area, volume, slope obtained two calculation methods. Ellipse Method used graphics tool draw elliptical borders circumscribing region interest image. software automatically calculated values for all parameters inside ellipse, retinal reference plane adjusted match height surrounding retina. User-Defined Region differed that was drawn manually. Results PEDs easily detected TopSS. Maximum above ranged 0.204 1.818 mm 0.57 mm). diameter 0.501 5.151 2.711 mm), area 0.179 20.402 2 6.585 ), volume 0.012 13.981 3 2.173 ). Intraobserver variability low, correlations between first second measurements visit ranging r 0.906 0.997 respectively. Conclusions analysis TopSS provides objective measures not obtainable typical clinical methods such as fundus photography angiography. Height are crucial determining whether neovascularization is worsening or persistent after photocoagulation. More longitudinal needed determine tomographic reduce need Unique scanning laser tomography, exudative features imaged at different depths.