Pharmacodynamics and pharmacokinetics of antibiotics with special reference to the fluoroquinolones.

摘要: The pharmacodynamic and pharmacokinetic properties of antibiotics have received increased attention in recent years, leading to optimization dosage regimens. In view these characteristics, certain fluoroquinolones may prove advantageous compared with other antimicrobials for treatment selected infections. Several new fluoroquinolone antimicrobial agents potency equal or greater than that beta-lactam against gram-negative aerobic bacilli, including Pseudomonas aeruginosa. vitro bactericidal activity compounds is more rapid the beta-lactams, often resembling aminoglycosides. Like aminoglycosides, but contrast exert a significant postantibiotic effect some strains P. aeruginosa Enterobacteriaceae. However, unlike many aminoglycoside similar activity, are effective both after oral parenteral administration. Important include differences extent variability absorption clearance, which determine vivo exposure drug. Drugs regimens result high degree exposure, particularly peak levels drug, be preferable because bacterial killing less selection drug-resistant bacteria.