Evaluation of Intravenous Ciprofloxacin in Patients With Nosocomial Lower Respiratory Tract Infections

摘要: • Fifty patients with gram-negative lower respiratory tract infections were treated intravenous ciprofloxacin to evaluate efficacy and safety. Relationships between individual pharmacokinetics clinical bacteriologic outcome studied. Ciprofloxacin concentrations in plasma determined by high-performance liquid chromatography. Respiratory secretion cultures obtained daily determine the eradication day of infecting organism. Susceptibility (minimum inhibitory concentration) other antimicrobials was using standard microdilution techniques. The mean age 70 years. They had multiple underlying diseases, two thirds them ventilator dependent at entry. Approximately 50% failed previous treatment for same infections. Patients infected Enterobacteriaceae or Haemophilus influenzae minimum less than 0.25 mg/L responded well therapy (200 mg every 12 hours). organisms eradicated from sputum usually within 1 after started. Most failures occurred who Pseudomonas aeruginosa diseases. isolated 10 pneumonia, 2 lung abscess, patient bronchiectasis. isolate acquired resistance during 7 pneumonia all remaining 3 patients. We conclude that is safe effective a dosage 200 administered intravenously hours nosocomial caused species. Many antibiotic good response therapy. Studies either higher dosages combination should be conducted if can avoided ( Arch Intern Med . 1989;149:2269-2273)