Gene Mutations and Transcriptomic Profiles Associated to Specific Subtypes of Hepatocellular Tumors

摘要: Benign hepatocellular tumors mainly include focal nodular hyperplasia and adenomas whereas malignant are essentially represented by carcinomas. Hepatocarcinogenesis is a complex multi-step process leading to the accumulation of large number genetic epigenetic alterations both in benign tumors. These also characterized clinical broad diversity that includes spectrum different risk factors, several pathological phenotypes, presentations. Recently, comprehensive transcriptomic profiling enabled identification new molecular classifications closely related phenotypic these Because almost all mutations oncogenes tumor suppressor genes, results revealed events as major determinants diversity. Finally, classifying homogeneous subgroups promising tool develop personalized medicine future.