Human intestinal intraepithelial lymphocytes are derived from a limited number of T cell clones that utilize multiple V beta T cell receptor genes.

摘要: Intestinal intraepithelial lymphocytes (IEL) are a phenotypically distinct T cell population of unknown function. The majority human intestinal IEL express the TCR-alpha beta, CD8 accessory molecule, and CD45RO Ag, suggesting that they MHC class I-restricted memory cells. Recent analyses TCR alpha- beta-chains expressed by these cells have shown marked skewing toward one or several V region genes in individual donors revealed presence clonally expanded In addition, functional data has suggested I-like CD1 molecules may be target ligands for some clones. This report examines detail TCR-beta repertoire jejunal to determine what fraction whether particular subset beta utilized results demonstrate derived from expansion relatively few clones can utilize large number different genes. Oligoclonal is also demonstrated among lamina propria (LPL), with overlapping but detected LPL vs populations. These indicate most IEL-alpha subpopulation LPL, specific limited Ag place constraints on possible roles played defense against diverse environmental pathogens generation oral tolerance.