Anticonvulsant activity of MK-801 and Nimodipine alone and in combination against pentylenetetrazole and strychnine
作者： Sean K. O'Neill , Gordon T. Bolger
DOI: 10.1016/0091-3057(89)90003-8
关键词:
摘要: The effects of the N-methyl-D-aspartate receptor antagonist MK-801 and dihydropyridine calcium channel nimodipine were assessed for their anticonvulsant activity alone in combination against clonic convulsions to pentylenetetrazole (PTZ) strychnine (STR) mice. Nimodipine (2-20 mg/kg) (0.1 0.5 did not affect number mice displaying PTZ. However, a dose-dependent manner increased (100%) latency lethality (mortality from tonic extension respiratory failure) following In contrast, increase PTZ convulsions, but prevented lethal When combined, produced significant reduction animals (40-60%) greater than alone. decreased onset time, severity STR convulsions. A which afforded protection These findings suggest that nimodipine, while possessing on own, produce potent synergism STR.
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