Phencyclidine and MK-801: a behavioral and neurochemical comparison of their interactions with dihydropyridine calcium antagonists.
作者： S.K. O'neill , G.T. Bolger
DOI: 10.1016/0361-9230(89)90078-6
关键词: Nitrendipine 、 Nifedipine 、 Antagonist 、 Convulsion 、 Pharmacology 、 Anticonvulsant 、 Dihydropyridine 、 Chemistry 、 Neurochemical 、 Endocrinology 、 Phencyclidine 、 Internal medicine
摘要: The impairment of rotarod ability and the convulsive activity phencyclidine (PCP) MK-801 were compared in male CD-1 mice. putative interaction between nifedipine PCP on these behavioral measurements was also quantitated compared. produced a dose dependent inhibition with an ED50 0.5 mg/kg. Nifedipine potentiated by MK-801. Both behavior mice which characterized jumping wild running fits; CD50 for 1.3 dependently inhibited convulsions associated PCP. but not increased [3H]nitrendipine binding to dihydropyridine (DHP) sites mouse brain membranes. blocked effects binding. These findings suggest that is potent PCP-like drug interacts neuronal DHP sites. Nifedipine's reduction hyperactivity elicited may be importance eventual development as antiischaemic anticonvulsant drug.
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