Glycine potentiates N-methyl-d-aspartate-induced [3H]TCP binding to rat cortical membranes
作者： Lawrence D. Snell , Robert S. Morter , Kenneth M. Johnson
DOI: 10.1016/0304-3940(87)90106-6
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摘要: Abstract In extensively washed preparations of rat cortical membranes, N- methyl- d -aspartate (NMDA) increases the specific binding [3H]TCP by over 4-fold in a concentration dependent manner (EC50 = 3.1 μM). Glycine (1 μM) potentiates maximal effect NMDA factor 1.7. The glycine is 380 nM) and strychnine insensitive. These data are discussed with reference to recently reported effects on operated cation channel relationship between PCP receptors.
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