Linkage between phencyclidine (PCP) and N-methyl-D-aspartate (NMDA) receptors in the cerebellum.
作者： Su-Jin Yi , Lawrence D. Snell , Kenneth M. Johnson
DOI: 10.1016/0006-8993(88)91084-0
关键词: Cortex (botany) 、 Long-term depression 、 Phencyclidine 、 Norepinephrine 、 Biochemistry 、 Chemistry 、 NMDA receptor 、 Pharmacology 、 D aspartate 、 Receptor 、 Cerebellum
摘要: Abstract It has been suggested that phencyclidine (PCP) receptors may not be linked with N- methyl- d -aspartate (NMDA) in all brain areas. We found NMDA enhanced [3H]TCP (a PCP analog) binding extensively washed cortical, but cerebellar membranes. However, potently inhibited NMDA-induced [3H]norepinephrine release from slices a concentration-dependent manner, suggesting subtype of is functionally receptors. this cannot demonstrated by because the predominance low affinity cerebellum.
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elsevier.com参考文章(17)
Lawrence D. Snell, Robert S. Morter, Kenneth M. Johnson, Glycine potentiates N-methyl-d-aspartate-induced [3H]TCP binding to rat cortical membranes Neuroscience Letters. ,vol. 83, pp. 313- 317 ,(1987) , 10.1016/0304-3940(87)90106-6
DT Monaghan, CW Cotman, Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain The Journal of Neuroscience. ,vol. 5, pp. 2909- 2919 ,(1985) , 10.1523/JNEUROSCI.05-11-02909.1985
Graham E. Fagg, Phencyclidine and related drugs bind to the activated N-methyl-D-aspartate receptor-channel complex in rat brain membranes. Neuroscience Letters. ,vol. 76, pp. 221- 227 ,(1987) , 10.1016/0304-3940(87)90719-1
L. Nowak, P. Bregestovski, P. Ascher, A. Herbet, A. Prochiantz, Magnesium gates glutamate-activated channels in mouse central neurones Nature. ,vol. 307, pp. 462- 465 ,(1984) , 10.1038/307462A0
D. Martin, D. Lodge, Ketamine acts as a non-competitive N-methyl-d-aspartate antagonist on frog spinal cord in vitro Neuropharmacology. ,vol. 24, pp. 999- 1003 ,(1985) , 10.1016/0028-3908(85)90128-5
Francis Crepel, Jean-Luc Dupont, Robert Gardette, Voltage clamp analysis of the effect of excitatory amino acids and derivatives on Purkinje cell dendrites in rat cerebellar slices maintained in vitro Brain Research. ,vol. 279, pp. 311- 315 ,(1983) , 10.1016/0006-8993(83)90200-7
Susan M. Jones, L.D. Snell, K.M. Johnson, Inhibition by phencyclidine of excitatory amino acid-stimulated release of neurotransmitter in the nucleus accumbens. Neuropharmacology. ,vol. 26, pp. 173- 179 ,(1987) , 10.1016/0028-3908(87)90206-1
Pat Loo, Albert Braunwalder, John Lehmann, Michael Williams, Radioligand binding to central phencyclidine recognition sites is dependent on excitatory amino acid receptor agonists. European Journal of Pharmacology. ,vol. 123, pp. 467- 468 ,(1986) , 10.1016/0014-2999(86)90726-0
J. W. Johnson, P. Ascher, Glycine potentiates the NMDA response in cultured mouse brain neurons Nature. ,vol. 325, pp. 529- 531 ,(1987) , 10.1038/325529A0
MM Bradford, None, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Analytical Biochemistry. ,vol. 72, pp. 248- 254 ,(1976) , 10.1016/0003-2697(76)90527-3