NMDA-, but not kainate- or quisqualate-dependent increases in cerebellar cGMP are dependent upon monoaminergic innervation.
作者： P.L. Wood , R. Ryan , M. Li
DOI: 10.1016/0024-3205(92)90163-J
关键词:
摘要: Abstract As previously reported, intracerebellar injectors of D-serine, quiaqualate and kainate elevated mouse cerebellar cGMP levels. Similarly, activation endogenous excitatory amino acid utilizing neurons with harmaline or pentylenetetrazole also increased cGMP. We have demonstrated that the harmaline- pentylenetetrazol-dependent increases are NMDA receptor mediated. In this report we further NMDA-dependent in dependent upon monoaminergic innervation cerebellum, while kainate- quisqualate-dependent independent such innervation.
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