Allosteric Modulation of N-Methyl-D-Aspartate Receptors
作者： Ian J. Reynolds , Richard J. Miller
DOI: 10.1016/S1054-3589(08)60340-3
关键词:
摘要: Publisher Summary This chapter discusses the allosteric modulation of N–methyl-D-aspartute (NMDA) receptors. It focuses on NMDA-preferring glutamate receptor. NMDA receptors are involved in a wide range physiological and pathophysiological events, this has resulted great deal interest development tools to probe manipulate receptor function. Moreover, many studies have demonstrated that activity can be modulated by endogenous agents. The purpose chapter, therefore, is examine actions known modulators terms their binding sites, try determine how these sites interact with each other. By understanding interactions between it may possible comprehend better operate different circumstances, also target more accurately therapeutic agents interrupt specific receptor-mediated events.
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