Motor activation in short- and long-term reserpinized mice: role of , dopamine D1 and dopamine D2 receptors

摘要: Abstract The effects of dopamine D1 and D2 receptor agonists subconvulsant doses N- methyl- D -aspartate (NMDA) the non-competitive NMDA antagonist, dizocilpine (MK-801), alone in combination, on motor activity short- long-term reserpinized mice (mice pretreated with 5 mg/kg reserpine 4 h or 20 before, respectively) were analyzed. With short-term reserpinization, agonist, quinpirole (1.5 mg/kg), but not SKF-38393 (15 increased activity. effect was potentiated by simultaneous administration mg/kg) counteracted previous raclopride (1 (25 MK-801 (0.5 mg/kg). Neither (25–100 nor (0.5–3 induced activation mice. either concurrent inhibited modified concomitant slightly antagonized at which similar to those causing non-reserpinized (75 100 while a dose associated depression (2 NMDA-induced low still present when stronger dopamine-depleting pretreatment used. These results are interpreted basis changes sensitivity direct striatal efferent pathway after reserpinization.