Motor depressant effects of systemically administered polyamines in mice: involvement of central NMDA receptors.

摘要: Abstract The systemic administration of polyamines (s.c.) produced a dose-dependent motor depression. With high doses the depressant effect was long-lasting and animals showed signs toxicity. ED50 values for spermidine putrescine were 38, 90 251 mg/kg respectively. depression induced by N-methyl- d -aspartate (NMDA; 25 i.p.) used as model studying interactions between NMDA receptor. Results indicate that (1) effects elicited are very similar to those at doses; (2) polyamines, even non-active doses, potentiate NMDA; (3) receptor antagonist, (5R,10S)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801; 0.5 i.p.), abolishes toxic (4) amphetamine (1.5 does not counteract or polyamines. On other hand, adenosine theophylline (30 counteracts NMDA- but polyamine-induced concentration in brain is modified after their dose putrescine. In conclusion, data suggest could be target mediating They also show quantitative analysis non-convulsant might powerful tool vivo interaction neurotransmission systems involved regulation activity.