Excitatory amino acid binding sites in the basal ganglia of the rat: A quantitative autoradiographic study

摘要: Quantitative receptor autoradiography was used to determine the distribution of excitatory amino acid binding sites in basal ganglia rat brain. a-Amino-3-hydroxy-5-methylisoxazole-4- propionic acid, N-methyl-D-aspartate, kainate, quisqualate-sensitive metabotropic and non-N-methyl-D- aspartate, non-kainate, non-quisqualate glutamate had their highest density striatum, nucleus accumbens, olfactory tubercle. Kainate higher lateral striatum but there no medial-lateral striatal gradient for other sites. N-Methyl-D-aspartate a-amino-3- hydroxy-5-methylisoxazole-4-propionic were most dense accumbens There dorsal-ventral within complex Other regions lower densities ligand binding. To compare site non-striatal regions, each normalized density. When compared complex, a-amino-3-hydroxy-5-methylisoxazole-4-propionic relative globus pallidus, ventral pallidum, subthalamic than Metabotropic also a high substantia nigra. Non-N-methyl-D-aspartate, N-Methyl-D-aspar- tate low nucleus, nigra tegmental area. Our data indicate heterogeneous suggest that character acid-mediated neurotransmission is heterogeneous. The are group interconnected subcortical nuclei spanning telencephalon, dien- cephalon, mesencephalon. While functions incompletely understood, it known from both human clinical experimental animal studies involved organization wide variety motor non-motor behaviors. Biochemical, physiological, be- havioral, immunocytochemical acids (EAAs) important neuro- transmitters afferents some circuits (see below). best studied these pathways corticostri- ate projection, where biochemical,6~13~24~29~30~40~"~70.75.80.94