S-nitroso-N-acetylcysteine protects skeletal muscle against reperfusion injury.
作者： Kang Liu , Long-En Chen , Anthony V. Seaber , James R. Urbaniak
DOI: 10.1002/(SICI)1098-2752(1998)18:5<299::AID-MICR1>3.0.CO;2-J
关键词:
摘要: The effects of a nitric oxide (NO) donor on microcirculation and contractile function reperfused skeletal muscle were studied. Rat cremaster muscles underwent 5 hours ischemia 90 minutes reperfusion divided into two groups systemically infused with S-nitroso-N-acetylcysteine (SNAC, 100 nmol/min) phosphate-buffered saline (PBS), respectively. results showed that the vessels in SNAC group had more rapid complete recovery than controls. A significant difference was found from 10 to 40 at 10-20-microm arterioles, 20-40-microm 40-70-microm arteries. When compared controls, SNAC-treated larger fluorescein filling areas 15, 30, 60, greater isometric tetanic forces response stimulation frequencies 40, 70, 100, 120 Hz. data indicate supplementation exogenous NO could effectively improve during early reperfusion.
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