Stage-IV melanoma and pulmonary metastases: factors predictive of survival.

摘要: We reviewed a contemporary, single-institution experience to evaluate the natural history of stage-IV melanoma metastatic lung and identify factors predictive survival. A search our prospective database was performed patients with pulmonary metastases as initial disease site; only seen at institution prior developing in whom treatment response available were included. Patients’ demographic, clinical, variables recorded. Cox regression used independently The study cohort comprised 122 patients. Median survival 14 months (5-year 8%). Clinical time diagnosis stage IV solitary metastasis (HR 2.7, CI 1.6–4.4, P<0.0005) absence extra-pulmonary 1.9, 1.2–3.1, P = 0.01). Among factors, metastasectomy 0.42, 0.21–0.87, 0.02). Of patients, 26 (21%) underwent metastasectomy, median 40 compared 13 not selected for surgical treatment. these 26, 23 (88%) experienced recurrence 5 after procedure. No difference between responders non-responders systemic therapy (P 0.55). In metastases, are While often present this predicts However, does correlate difference.