Total antioxidant capacity of the diet is inversely and independently related to plasma concentration of high-sensitivity C-reactive protein in adult Italian subjects

摘要: Inflammation, a risk factor for cardiovascular disease, is associated with low plasma levels of antioxidant vitamins. In addition to vitamins, other antioxidants modulate the synthesis inflammatory markers in vitro and contribute total capacity (TAC) diet. However, relationship between dietary TAC inflammation has never been evaluated vivo. We investigated systemic (high-sensitivity C-reactive protein (hs-CRP), leucocytes) vascular (soluble intercellular cell adhesion molecule-1) 243 non-diabetic subjects. General Linear Model (GLM) analysis showed significant (P=0.005) inverse hs-CRP quartiles energy-adjusted TAC, even when recognized modulating factors inflammation, namely alcohol, fibre, vitamin C, alpha-tocopherol, beta-carotene, BMI, waist circumference, HDL-cholesterol, hypertension, insulin sensitivity were included model as covariates (P=0.004). The was stronger subjects hypertension (P=0.013 v. P=0.109 normotensive individuals). Among factors, significantly higher (5.3 (sd 3.0) 4.9 2.7) mmol Trolox/d; P=0.026) (range: 0.0-4.1 mg/l) than high 4.2-27.8 mg/l). conclude that inversely independently correlated concentrations this could be one mechanisms explaining protective effects against CVD antioxidant-rich foods such fruits, whole cereals red wine. This particular significance blood pressure.