Regulation of interleukin 1 gene expression by adherence and lipopolysaccharide.

摘要: Murine peritoneal exudate cells (PEC), analyzed immediately after isolation, did not express detectable IL 1 activity or 1-specific mRNA. Stimulation of these by adherence induced the expression intracellular, membrane, and extracellular activities within 4 hr. Analysis mRNA from showed a concurrent induction both alpha beta However, this stimulation was transient, since PEC cultured for 5 days no longer expressed bioactivity specific quiescent with bacterial lipopolysaccharide re-expression as well We found qualitative difference in degree rate compared These results indicate that resting macrophages are negative, inducing stimuli used study act transiently to increase levels