Effects of SHIP-1 on MMP2 Secretion and Invasion of SR3Y1 Cells
作者： Wanjin Xing , Michinari Hamaguchi
DOI: 10.1016/S1673-8527(07)60030-7
关键词:
摘要: SHIP-1 is an SH2 domain containing inositol-5-phosphatase that appears to be a negative regulator of hematopoiesis. To the potential effects on MMP2 secretion and migration cancer cells, three murine mutants were made: DeltaSH2-SHIP-1, DeltaPtase-SHIP-1, DeltaCter-SHIP-1. These mutant forms subcloned as well wild type (WT) cDNA into pcDNA3 expression vector, then transfected overexpressed its in Src-transformed 3Y1 cell line (SR3Y1). The results showed overexpression does not affect both SR3Y1 but can induce MMP9 secretion, while either WT SHIP-1, domain, phosphatase or C terminus deletion could significantly block cells suppress invasion ability. confirmed for transformed implied it may function through each domains.
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