Clinical Applications for the Central Nervous System
作者： Dominique Delbeke
DOI: 10.1007/978-0-387-22453-4_4
关键词:
摘要: The glucose metabolism of the brain can be evaluated using analog, 18F-fluorodeoxyglucose (FDG). FDG is transported into cells by same mechanism as glucose. then phosphorylated a hexokinase FDG-6-phosphate. As tissue does not have glucose-6-dephosphatase, FDG-6-phosphate cannot progress further glycolytic pathways, so it accumulates proportional to rate cells. cortex normally only uses its substrate; therefore, accumulation high. Because dedicated PET systems with full rings bismuth germanate oxide (BGO) detectors provide for soft attenuation and are calibrated an external source known activity germanium, true count rates measured over region interest. Dynamic scanning after injection dynamic arterial blood sampling obtain both plasma tracer concentrations time permit quantification actual metabolic kinetic modeling.
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