Protein Expressions and Genetic Variations of SLC5A8 in Prostate Cancer Risk and Aggressiveness

作者: Hui-Yi Lin , Hyun Y. Park , Selina Radlein , Nupam P. Mahajan , Thomas A. Sellers

DOI: 10.1016/J.UROLOGY.2011.04.055

关键词:

摘要: OBJECTIVES Previous studies suggest that SLC5A8 may function as a tumor suppressor gene whose silencing by epigenetic changes contribute to carcinogenesis. To understand role in prostate cancer risk and aggressiveness, we investigated expression single nucleotide polymorphisms (SNPs) of SLC5A8.

参考文章(30)
Jong Park, Romulo Martin Brena, Mike Gruidl, Jun Zhou, Tim Huang, Christoph Plass, Melvyn S. Tockman, CpG island hypermethylation profiling of lung cancer using restriction landmark genomic scanning (RLGS) analysis. Cancer Biomarkers. ,vol. 1, pp. 193- 200 ,(2005) , 10.3233/CBM-2005-12-307
J C Long, R C Williams, M Urbanek, An E-M algorithm and testing strategy for multiple-locus haplotypes American Journal of Human Genetics. ,vol. 56, pp. 799- 810 ,(1995)
Hui Li, Lois Myeroff, Dominic Smiraglia, Michael F Romero, Theresa P Pretlow, Lakshmi Kasturi, James Lutterbaugh, Ronald M Rerko, Graham Casey, Jean-Pierre Issa, Joseph Willis, James KV Willson, Christoph Plass, Sanford D Markowitz, None, SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 8412- 8417 ,(2003) , 10.1073/PNAS.1430846100
Elangovan Gopal, Seiji Miyauchi, Pamela M. Martin, Sudha Ananth, Penny Roon, Sylvia B. Smith, Vadivel Ganapathy, Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract. Pharmaceutical Research. ,vol. 24, pp. 575- 584 ,(2007) , 10.1007/S11095-006-9176-1
Hui-Yi Lin, Wenquan Wang, Yung-Hsin Liu, Seng-Jaw Soong, Timothy P. York, Leann Myers, Jennifer J. Hu, Comparison of multivariate adaptive regression splines and logistic regression in detecting SNP-SNP interactions and their application in prostate cancer Journal of Human Genetics. ,vol. 53, pp. 802- 811 ,(2008) , 10.1007/S10038-008-0313-Z
Kristi L. Bennett, Matthew Karpenko, Mau-ting Lin, Rainer Claus, Khelifa Arab, Gerhard Dyckhoff, Peter Plinkert, Esther Herpel, Dominic Smiraglia, Christoph Plass, Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma Cancer Research. ,vol. 68, pp. 4494- 4499 ,(2008) , 10.1158/0008-5472.CAN-07-6509
Muthusamy Thangaraju, Gail Cresci, Shiro Itagaki, John Mellinger, Darren D. Browning, Franklin G. Berger, Puttur D. Prasad, Vadivel Ganapathy, Sodium-Coupled Transport of the Short Chain Fatty Acid Butyrate by SLC5A8 and Its Relevance to Colon Cancer Journal of Gastrointestinal Surgery. ,vol. 12, pp. 1773- 1782 ,(2008) , 10.1007/S11605-008-0573-0
Shuiying Hu, Dingxie Liu, Ralph P. Tufano, Kathryn A. Carson, Eli Rosenbaum, Yoram Cohen, Elizabeth H. Holt, Katja Kiseljak-Vassiliades, Kerry J. Rhoden, Sara Tolaney, Stephen Condouris, Giovanni Tallini, William H. Westra, Christopher B. Umbricht, Martha A. Zeiger, Joseph A. Califano, Vasily Vasko, Mingzhao Xing, Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer. International Journal of Cancer. ,vol. 119, pp. 2322- 2329 ,(2006) , 10.1002/IJC.22110
J Ahn, , S C Moore, D Albanes, W-Y Huang, M F Leitzmann, R B Hayes, Height and risk of prostate cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. British Journal of Cancer. ,vol. 101, pp. 522- 525 ,(2009) , 10.1038/SJ.BJC.6605159
Muthusamy Thangaraju, Elangovan Gopal, Pamela M. Martin, Sudha Ananth, Sylvia B. Smith, Puttur D. Prasad, Esta Sterneck, Vadivel Ganapathy, SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases. Cancer Research. ,vol. 66, pp. 11560- 11564 ,(2006) , 10.1158/0008-5472.CAN-06-1950