Functional and clinical significance of hepatitis D virus genotype II infection.

摘要: Hepatitis D virus (HDV) infection is one of the important etiologies fulminant hepatitis and may aggravate clinical course chronic HBV to cirrhosis liver failure. HDV was classified into three genotypes. Recent molecular phylogenetic analysis suggests at least seven major clades. The genotype IHDV widely spread, II found in East Asia III prevalent South America. genomic size 1682–1685 nucleotides (nt) for II, 1676 nt IV (IIb). divergence nucleic acid sequences between other genotypes varies from 13.8% 35.3%. divergences HDAg-coding region range 17.8% 29.8% There no genotypic or restriction on interactions either small large delta antigens (HDAgs) I there also incompatibility during co-package HDAgs different like particles. appears apparent universal transactivation RNA replication by HDAg II. In contrast, more transactivate replication. Of functional domains HDAg, 19 amino acids carboxyl-end show greatest (70%–80%) viral packaging efficiencies isolates are usually higher than those seem be most determinant efficiencies. editing Genotype relatively less frequently associated with acute stage unfavorable outcomes [cirrhosis hepatocellular carcinoma (HCC)] as compared I. It that manifestations patients (IIb) infection. Persistent adverse (cirrhosis, HCC mortality) who cleared both viruses sera. C a significant factor addition age. However, have low undetectable B DNA levels. During longitudinal follow-up, survival.