Safety Issues in MSC Therapy
作者： Minoo Battiwalla , A. John Barrett
DOI: 10.1007/978-1-4614-5711-4_20
关键词:
摘要: Multipotent mesenchymal stromal cells (MSCs) have enormous therapeutic potential because of their unique biological properties related to proliferative potential, differentiation capability, lack immunogenicity, immunosuppressive nature, homing ability, tissue repair, and cytokine production. However, the very that drive enthusiasm for MSCs as cellular therapy could potentially impact safety. Most troublesome is risk promoting malignancy demonstrated in animal models. Culture conditions (media, passage length), donor (autologous versus allogeneic), source (marrow, cord, placental, or adipose tissue), indication (transplant cardiovascular regeneration) are additional variables may influence safety profile.
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