Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts.

摘要: The role of myofibroblasts in tissue repair and fibrosis is well documented, but the source these unclear. There evidence a circulating population fibrocytes that can home to areas injury contribute myofibroblast populations. Previously, we have shown bone marrow for many tissues including gut, lung, kidney this phenomenon exacerbated by injury. We now show fibroblast populations tumor stroma mouse model pancreatic insulinoma. Mice transgenic rat insulin promoter II gene linked large-T antigen SV40 (RIPTag) develop solid β-cell tumors pancreas. Approximately 25% were donor-derived, concentrated toward edge tumor. Thus, development at least part systemic response may ultimately yield methods targeting new therapy.