Molecular Targeted Therapies in Pancreatic Cancer

摘要: Pancreatic cancer, one of the deadliest malignancies, is a complex disease consisting heterogeneous cancer cells with deregulated signaling pathways and myriad microenvironment cells, including infiltrating immune fibroblasts, that impact tumor growth susceptibility to conventional chemotherapy. Understanding drive pancreatic crucial development novel targeted therapies combat disease, which largely refractory therapeutic options. Among these are Hedgehog, NOTCH, Wnt, MET, TGF-β control not only bulk growth, but also self-renewal stem maintenance desmoplastic stroma characteristic disease. In addition altered pathways, many within promote both serve as barrier Here we will discuss how targeting components may increase efficacy it treated.