Bioreducible Hydrophobin-Stabilized Supraparticles for Selective Intracellular Release.

摘要: One of the main hurdles in nanomedicine is low stability drug–nanocarrier complexes as well drug delivery efficiency region-of-interest. Here, we describe use film-forming protein hydrophobin HFBII to organize dodecanethiol-protected gold nanoparticles (NPs) into well-defined supraparticles (SPs). The obtained SPs are exceptionally stable vivo and efficiently encapsulate hydrophobic molecules. film prevents massive release encapsulated drug, which, instead, activated by selective SP disassembly triggered intracellularly glutathione reduction film. As a consequence, therapeutic an anticancer highly enhanced (2 orders magnitude decrease IC50). Biodistribution pharmacokinetics studies demonstrate high loaded bloodstream payloads once taken up tissues. Overall, our results provide rationale for development o...