Genetic control of responses to Trypanosoma cruzi in mice: multiple genes influencing parasitemia and survival.

摘要: Inbred strains of mice can be divided into two groups based on the level parasitemia which develops after injection with 10(3) trypomastigotes Trypanosoma cruzi (Peru). Strains developed parasitemias greater than 10(7) per ml by day 17, including C3H/HeJ, BALB/c, and CBA/N mice, were termed high strains. Low strains, C57BL/6J DBA/2J less 5 x 10(6) 17 infection. Congenic from C57BL/10J, C57BL/6J, BALB/c backgrounds differed at H-2 region injected to determine effect locus response The had no attained during However, one strain, B10.S (H-2s), was unusual in that most survived results infection F1 hybrid progeny T. (Peru) suggest low inherited a dominant manner survival may influenced several other genes. inbred as measured time, One or more genes, located outside region, involved regulating reached Another H-2-linked gene(s) appeared unique H-2s haplotype.