Paraflagellar rod proteins administered with alum and IL-12 or recombinant adenovirus expressing IL-12 generates antigen-specific responses and protective immunity in mice against Trypanosoma cruzi
作者： Ruth A Wrightsman , Jerry E Manning
DOI: 10.1016/S0264-410X(99)00380-1
关键词:
摘要: Successful vaccination of mice against an otherwise lethal challenge with the Peru strain Trypanosoma cruzi necessitates induction a strong cell mediated immune response. Previously, immunization paraflagellar rod proteins from cruzi90% reduction in parasitemia immunized challenged bloodstream stage cruzi.
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M J Skeen, H K Ziegler, M A Miller, Nonviable bacterial antigens administered with IL-12 generate antigen-specific T cell responses and protective immunity against Listeria monocytogenes. Journal of Immunology. ,vol. 155, pp. 4817- 4828 ,(1995)
P Caspar, A Sher, D Jankovic, F R Vogel, M Zweig, S D Showalter, M Garcia-Moll, Adsorption to aluminum hydroxide promotes the activity of IL-12 as an adjuvant for antibody as well as type 1 cytokine responses to HIV-1 gp120. Journal of Immunology. ,vol. 159, pp. 2409- 2417 ,(1997)
P C Familletti, A G Wolitzky, D S Schoenhaut, U Gubler, M K Gately, P M Quinn, C M Dwyer, W McComas, A O Chua, Cloning and expression of murine IL-12. Journal of Immunology. ,vol. 148, pp. 3433- 3440 ,(1992)
Jack Gauldie, Claudia Raja Gabaglia, Eli E. Sercarz, Frank L. Graham, Brian Pedersen, Mary Hitt, Nicolas Burdin, Todd A. Braciak, A Single Intramuscular Injection with an Adenovirus- Expressing IL-12 Protects BALB/c Mice Against Leishmania major Infection, While Treatment with an IL-4-Expressing Vector Increases Disease Susceptibility in B10.D2 Mice Journal of Immunology. ,vol. 162, pp. 753- 760 ,(1999)
S G Reed, In vivo administration of recombinant IFN-gamma induces macrophage activation, and prevents acute disease, immune suppression, and death in experimental Trypanosoma cruzi infections. Journal of Immunology. ,vol. 140, pp. 4342- 4347 ,(1988)
D K Dalton, M Croft, L M Bradley, A direct role for IFN-gamma in regulation of Th1 cell development. Journal of Immunology. ,vol. 157, pp. 1350- 1358 ,(1996)
C.A. Beard, J.L. Saborio, D Tewari, K.G. Krieglstein, A.H. Henschen, J.E. Manning, Evidence for two distinct major protein components, PAR 1 and PAR 2, in the paraflagellar rod of Trypanosoma cruzi. Complete nucleotide sequence of PAR. Journal of Biological Chemistry. ,vol. 267, pp. 21656- 21662 ,(1992) , 10.1016/S0021-9258(19)36662-1
S Hieny, A W Cheever, T A Wynn, A Sher, D Jankovic, IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue eosinophilia. Journal of Immunology. ,vol. 154, pp. 4701- 4709 ,(1995)
G A Stryker, R A Wrightsman, M J Miller, J E Manning, Protection of mice against Trypanosoma cruzi by immunization with paraflagellar rod proteins requires T cell, but not B cell, function. Journal of Immunology. ,vol. 158, pp. 5330- 5337 ,(1997)
R Wrightsman, S Krassner, J Watson, Genetic control of responses to Trypanosoma cruzi in mice: multiple genes influencing parasitemia and survival. Infection and Immunity. ,vol. 36, pp. 637- 644 ,(1982) , 10.1128/IAI.36.2.637-644.1982