Endothelial Dysfunction and Specific Inflammation in Obesity Hypoventilation Syndrome

摘要: BACKGROUND: Obesity hypoventilation syndrome (OHS) is associated with increased cardiovascular morbidity. What moderate chronic adds to obesity on systemic inflammation and endothelial dysfunction remains unknown. QUESTION: To compare inflammatory status function in OHS versus eucapnic obese patients. METHODOLOGY: 14 39 patients matched for BMI age were compared. Diurnal blood gazes, overnight polysomnography function, measured by reactive hyperemia peripheral arterial tonometry (RH-PAT), assessed. Inflammatory (Leptin, RANTES, MCP-1, IL-6, IL-8, TNFalpha, Resistin) anti-inflammatory (adiponectin, IL-1Ra) cytokines multiplex beads immunoassays. PRINCIPAL FINDINGS: exhibited a higher PaCO(2), lower forced vital capacity (FVC) tended have PaO(2) than (HS)-CRP, RANTES levels glycated haemoglobin (HbA1c) significantly (respectively 11.1+/-10.9 vs. 5.7+/-5.5 mg x l(-1) 55.9+/-55.3 vs 23.3+/-15.8 ng/ml 7.3+/-4.3 6.1+/-1.7 HbA1c). Serum adiponectin was reduced (7606+/-2977 13,660+/-7854 ng/ml). Endothelial more impaired (RH-PAT index: 0.22+/-0.06 0.51+/-0.11). CONCLUSIONS: Compared obesity, specific increase the pro-atherosclerotic chemokine, decrease adipokine function. These three conditions are known be strongly an risk. TRIAL REGISTRATION: ClinicalTrials.gov NCT00603096.