Obesity hypoventilation syndrome: from sleep-disordered breathing to systemic comorbidities and the need to offer combined treatment strategies.

摘要: Obesity hypoventilation syndrome (OHS) is defined as a combination of obesity (body mass index ≥ 30 kg/m(2)), daytime hypercapnia (partial arterial carbon dioxide concentration ≥45 mm Hg) and sleep-disordered breathing after ruling out other disorders that may cause alveolar hypoventilation. Through the prism International Classification Functioning, OHS chronic condition associated with respiratory, metabolic, hormonal cardiovascular impairments, leading to decrease in daily life activities, lack social participation high risk hospitalization death. Despite its severity, largely underdiagnosed health-related costs are higher than those apnoeic or obese eucapnic patients. The present review discusses definition, epidemiology, physiopathology treatment modalities OHS. Although nocturnal positive airway pressure therapies represent first-line effective improving patient outcomes, there need offer combined strategies assess effect multimodal therapeutic on morbidity mortality.