Propofol as an induction agent in children: pain on injection and pharmacokinetics.
作者： M. VALTONEN , E. IISALO , J. KANTO , P. ROSENBERG
DOI: 10.1111/J.1399-6576.1989.TB02879.X
关键词:
摘要: The efficacy of lignocaine (1%) mixed with propofol in reducing pain on injection was studied 40 children undergoing elective surgery a double-blind, randomized comparison glucose (5%). pharmacokinetics single dose 2.5 mg/kg also eight participating the same study. Lignocaine (1 mg) significantly reduced compared to control group (P less than 0.001). induction characteristics were not affected by lignocaine, and no undesirable interaction found between two drugs. first-stage elimination half-life (t1/2 beta) shorter (mean 9.3 +/- 3.8 (s.d.) min) values adults. This pharmacokinetic alteration may have clinical significance following repeated administration or continuous infusion propofol.
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