The potential effect of imatinib against hypercholesterolemia induced atherosclerosis, endothelial dysfunction and hepatic injury in rabbits

摘要: Abstract Aims Imatinib is an effective tyrosine kinase inhibitor which has different therapeutic actions. The recent work demonstrated the possible beneficial effects of imatinib on progression atherosclerosis, endothelial dysfunction, and hypercholesterolemia-associated liver damage in rabbits. Main methods Animals had been distributed 4 groups: group 1 (non-treated): animals fed regular diet; 2 high cholesterol [HC]: 1% supplemented diet for 30 days; 3 (HC-Imatinib): diet+imatinib (0.01 g/kg daily, p.o) (Imatinib): with p.o). After thirty days, tissue samples blood were isolated to be detected biochemically, histologically, vitro analysis. Key findings HC exhibited significant elevations serum lipid parameters, CRP, ALT, AST ALP. Additionally, induced increases aortic hepatic MDA, NO PDGFR-β, while significantly reductions GSH, SOD PPARγ1. Moreover, produced impairment ACh-enhanced relaxation pathological changes. Histopathological examination HC-fed rabbits revealed steatosis compared non-treated group. administration decreases PPARγ1 animals. Furthermore, protected against attenuation ACh-induced changes tissues. Interestingly, could return ALP, PDGFR-β basal values. Significance observation reports that have effect atherosclerosis progression, vascular malfunction, (HCD)-fed