β2-Microglobulin Production and Secretion by Lymphocytes in Culture

摘要: A β 2 -microglobulin with molecular weight of 12,600 daltons was initially isolated from the urine and serum patients renal tubular insufficiency (1). Smithies Poulik (2) determined partial amino acid sequence this globulin found that 24 first 46 residues were homologous parts heavy chain G-1 myeloma protein. This suggested a structural relationship existed between constant region human IgG immunoglobulins. In spite relatedness, specific antisera against all known immunoglobulin chains (including secretory piece J-chain) did not react Subsequently, Peterson et al. (3) established complete protein 28 C H 3 domain An also recently dog (4), its related to origin.