Respiratory disease in very-low-birthweight infants after prenatal thyrotropin-releasing hormone and glucocorticoid
作者： R.A. Ballard , P.L. Ballard , M. Bracken , F.R. Moya , I. Gross
DOI: 10.1016/0140-6736(92)90337-3
关键词:
摘要: Abstract Although prenatal glucocorticoid treatment reduces neonatal respiratory morbidity, distress syndrome and chronic lung disease (CLD) develop in many very-low-birthweight infants despite therapy. To investigate the effect of additional with thyrotropin-releasing hormone (TRH), we did a multicentre, blinded, randomised trial. 404 women threatened preterm delivery at less than 32 weeks' gestation received betamethasone plus TRH (4 doses 400 μg 8-hourly) or placebo. 103 who were fully treated 1 500 g birthweight evaluated during period. (55 infants) not affect total incidence (47% vs 58% controls) severe (13% 25% controls, p=0·11). CLD (defined as requirement for supplemental oxygen 28 days after birth) developed significantly fewer TRH-treated (18% 44% p
sci-hub.se 参考文章(22)
Philip L. Ballard, Thyroid Hormones: Effects and Binding Hormones and Lung Maturation. pp. 197- 235 ,(1986) , 10.1007/978-3-642-82483-8_7
Philip L. Ballard, Antenatal Glucocorticoid Therapy: Clinical Effects Hormones and Lung Maturation. pp. 137- 172 ,(1986) , 10.1007/978-3-642-82483-8_5
Knuppel Ra, Angel Jl, Morales Wj, Sawai S, O'Brien Wf, Fetal lung maturation: the combined use of corticosteroids and thyrotropin-releasing hormone. Obstetrics & Gynecology. ,vol. 73, pp. 111- 116 ,(1989)
Andrew T Shennan, Michael S Dunn, Ame Ohlsson, Kathryn Lennox, Elizabeth M Hoskins, None, Abnormal pulmonary outcomes in premature infants: prediction from oxygen requirement in the neonatal period. Pediatrics. ,vol. 82, pp. 527- 532 ,(1988)
L J Van Marter, M Pagano, E N Allred, A Leviton, K C Kuban, Maternal Glucocorticoid Therapy and Reduced Risk of Bronchopulmonary Dysplasia Pediatrics. ,vol. 86, pp. 331- 336 ,(1990)
R. N. Howie, G. C. Liggins, A CONTROLLED TRIAL OF ANTEPARTUM GLUCOCORTICOID TREATMENT FOR PREVENTION OF THE RESPIRATORY DISTRESS SYNDROME IN PREMATURE INFANTS Pediatrics. ,vol. 50, pp. 515- 525 ,(1972)
David Warburton, Lance Parton, Sue Buckley, Lina Cosico, Greg Enns, Terry Saluna, Combined effects of corticosteroid, thyroid hormones, and beta-agonist on surfactant, pulmonary mechanics, and beta-receptor binding in fetal lamb lung. Pediatric Research. ,vol. 24, pp. 166- 170 ,(1988) , 10.1203/00006450-198808000-00005
E. L. Kaplan, Paul Meier, Nonparametric Estimation from Incomplete Observations Springer Series in Statistics. ,vol. 53, pp. 319- 337 ,(1992) , 10.1007/978-1-4612-4380-9_25
LINDA W. GONZALES, PHILIP L. BALLARD, ROBERT ERTSEY, MARY C. WILLIAMS, Glucocorticoids and thyroid hormones stimulate biochemical and morphological differentiation of human fetal lung in organ culture The Journal of Clinical Endocrinology and Metabolism. ,vol. 62, pp. 678- 691 ,(1986) , 10.1210/JCEM-62-4-678
P M Barker, M Markiewicz, K A Parker, D V Walters, L B Strang, Synergistic Action of Triiodothyronine and Hydrocortisone on Epinephrine-Induced Reabsorption of Fetal Lung Liquid Pediatric Research. ,vol. 27, pp. 588- 591 ,(1990) , 10.1203/00006450-199006000-00010