Innate Immunity in Toxoplasma gondii Infection

摘要: Publisher Summary Epithelial cells provide the first line of innate immunological host defense against oral T. gondii infection. During natural infections, Toxoplasma initially crosses intestinal epithelium, disseminates into deep tissues, and traverses biological barriers in placenta as well blood–brain blood–retina barriers. The adult gastrointestinal tract is largest mucosal area body contact with external environment. formidable task this single-cell layer epithelia to maintain a physical barrier exogenous stimuli yet allow for selective entry essential nutrients. populated by resident microflora, homeostasis source Maintenance bacterial numbers simultaneous protection potential pathogens (including gondii) acquired route, provided numerous nonimmunological factors, including that are both (gut motility, epithelial cell layer) chemical (gastric acid, pancreatic proteolytic enzyme, bile, mucus). This chapter discusses role individual compartments gutassociated lymphoid tissue (GALT) response parasite.