Inhibition of NF-κB Activity in T and NK Cells Results in Defective Effector Cell Expansion and Production of IFN-γ Required for Resistance toToxoplasma gondii
作者： Cristina M. Tato , Alejandro Villarino , Jorge H. Caamaño , Mark Boothby , Christopher A. Hunter
DOI: 10.4049/JIMMUNOL.170.6.3139
关键词:
摘要: … a requirement for NF-κB in NK cell activation. Furthermore, in vitro stimulation of CD4 + T … As a consequence, these mice are highly susceptible to toxoplasmosis, with death within 12 …
highwire.org
aai.org
researchgate.net 参考文章(47)
Eric Y. Denkers, Ricardo T. Gazzinelli, Regulation and Function of T-Cell-Mediated Immunity during Toxoplasma gondii Infection Clinical Microbiology Reviews. ,vol. 11, pp. 569- 588 ,(1998) , 10.1128/CMR.11.4.569
Kendra Speirs, Jorge Caamano, Michael H. Goldschmidt, Christopher A. Hunter, Phillip Scott, NF-κB2 Is Required for Optimal CD40-Induced IL-12 Production but Dispensable for Th1 Cell Differentiation Journal of Immunology. ,vol. 168, pp. 4406- 4413 ,(2002) , 10.4049/JIMMUNOL.168.9.4406
Soo Young Lee, David R. Kaufman, Ana L. Mora, Angela Santana, Mark Boothby, Yongwon Choi, Stimulus-dependent Synergism of the Antiapoptotic Tumor Necrosis Factor Receptor–associated Factor 2 (TRAF2) and Nuclear Factor κB Pathways Journal of Experimental Medicine. ,vol. 188, pp. 1381- 1384 ,(1998) , 10.1084/JEM.188.7.1381
S. Sanjabi, A. Hoffmann, H.-C. Liou, D. Baltimore, S. T. Smale, Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 12705- 12710 ,(2000) , 10.1073/PNAS.230436397
Guido Franzoso, Louise Carlson, Ljiljana Poljak, Elizabeth W. Shores, Suzanne Epstein, Antonio Leonardi, Alex Grinberg, Tom Tran, Tanya Scharton-Kersten, Miriam Anver, Paul Love, Keith Brown, Ulrich Siebenlist, Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture Journal of Experimental Medicine. ,vol. 187, pp. 147- 159 ,(1998) , 10.1084/JEM.187.2.147
W.-X. Zong, L. C. Edelstein, C. Chen, J. Bash, C. Gelinas, The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-κB that blocks TNFα-induced apoptosis Genes & Development. ,vol. 13, pp. 382- 387 ,(1999) , 10.1101/GAD.13.4.382
Leanne Harling-McNabb, Georgia Deliyannis, David C. Jackson, Steve Gerondakis, George Grigoriadis, Lorena E. Brown, Mice lacking the transcription factor subunit Rel can clear an influenza infection and have functional anti-viral cytotoxic T cells but do not develop an optimal antibody response International Immunology. ,vol. 11, pp. 1431- 1439 ,(1999) , 10.1093/INTIMM/11.9.1431
Takahiro S. Doi, Toshitada Takahashi, Osamu Taguchi, Takachika Azuma, Yuichi Obata, NF-κB RelA-deficient Lymphocytes: Normal Development of T Cells and B Cells, Impaired Production of IgA and IgG1 and Reduced Proliferative Responses Journal of Experimental Medicine. ,vol. 185, pp. 953- 961 ,(1997) , 10.1084/JEM.185.5.953
Jorge Caamaño, Linden Craig, James Alexander, Rodrigo Bravo, Christopher A. Hunter, The NF-kappa B family member RelB is required for innate and adaptive immunity to Toxoplasma gondii. Journal of Immunology. ,vol. 163, pp. 4453- 4461 ,(1999)
Mark R. Boothby, Ana L. Mora, David C. Scherer, Jeffrey A. Brockman, Dean W. Ballard, Perturbation of the T Lymphocyte Lineage In Transgenic Mice Expressing a Constitutive Repressor of Nuclear Factor (NF)-κB Journal of Experimental Medicine. ,vol. 185, pp. 1897- 1907 ,(1997) , 10.1084/JEM.185.11.1897