Vitamin K supplementation reduces serum concentrations of under-γ-carboxylated osteocalcin in healthy young and elderly adults
作者： Neil C Binkley , Diane C Krueger , Jean A Engelke , Andrea L Foley , John W Suttie
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摘要: BACKGROUND Subclinical vitamin K insufficiency, manifested by under-gamma-carboxylation of the bone matrix protein osteocalcin, may be common. OBJECTIVE Our objective was to delineate prevalence submaximal gamma-carboxylation as assessed response phylloquinone supplementation and evaluate effect this intervention on skeletal turnover in healthy North American adults. DESIGN Healthy subjects (n = 219), approximately equally distributed sex age (18-30 y >/=65 y), received daily (1000 microg) or placebo for 2 wk. Serum undercarboxylated osteocalcin (ucOC) total N:-telopeptides type I collagen (NTx), bone-specific alkaline phosphatase (BSAP), concentrations were measured at baseline after weeks 1 2. RESULTS At baseline, mean serum concentration lower young than old group; there no sex. Concomitantly, %ucOC highest lowest men (P: 1% decrease. Phylloquinone reduced but did not alter NTx BSAP concentration. CONCLUSIONS Usual dietary practices population provide adequate maximal carboxylation. other markers turnover.
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